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STEMCELL Technologies Mouse Recombinant LIF

Product Code. 17149461
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Product Code. 17149461 Supplier STEMCELL Technologies Supplier No. 78056.2

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Description

Leukemia inhibitory factor

  • Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that regulates a broad variety of developmental functions
  • After LIF binds to the LIF receptor (LIFR), LIFR associates with gp130 and activates JAK/STAT and MAPK signaling
  • LIFR activation of STAT3 is essential for maintaining the mouse embryonic stem cell phenotype
  • Produced by the endometrium, LIF plays an important autocrine and paracrine role in implantation by regulating proliferation, invasion, and differentiation of trophoblasts following blastocyst attachment
  • Human LIF can be used for the maintenance of mouse embryonic stem cells; however, mouse LIF cannot bind to the human receptor, thus rendering mouse LIF inactive
  • LIF is produced by CD4+ and activated regulatory T cells, and promotes Foxp3 expression, while repressing Th17 lineage-specific genes

Specifications

Name CDF, Cholinergic differentiation factor, D Factor, DIA, Differentiation-inducing factor, Differentiation inhibitory activity, Differentiation-stimulating factor, Emfilermin, Hepatocyte-stimulating factor III, HILDA, Leukemia inhibitory factor, MLPLI
Quantity 1000 μg
Cell Type Neurons; Pluripotent Stem Cells
Purity or Quality Grade ≥95%
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