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STEMCELL Technologies Mouse Recombinant CD40 Ligand
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Quantity:
100 μg
500 μg
Unit Size:
100µg
500µg
Description
- CD40 ligand is a type II transmembrane glycoprotein that belongs to the tumor necrosis factor (TNF) superfamily (Quezada et al.) CD40 ligand forms a bioactive homotrimer that exist as both soluble and membrane-bound forms (Khandekar et al.) CD40 ligand is expressed on T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells
- Its receptor, CD40, is expressed on B cells, dendritic cells, macrophages, monocytes, platelets, endothelial cells, and epithelial cells (van Kooten & Banchereau)
- Binding of CD40 ligand to CD40 stimulates B cell proliferation, immunoglobulin class switching, antibody secretion, and T cell-dependent humoral responses
- Dysregulation of CD40 ligand contributes to immune deficiency in HIV and AIDS (Rickert et al.) CD40 ligand has also been linked to the pathology of atherosclerosis, atherothrombosis, and restenosis (Hassan et al.)
Specifications
Specifications
| Name | Cluster of differentiation 40, gp39, T-BAM, T-cell antigen Gp39, TNF-related activation protein, TNFSF5, TRAP, Tumor necrosis factor ligand superfamily member 5 |
| Quantity | 100 μg |
| Cell Type | B Cells; Dendritic Cells; Endothelial Cells; Granulocytes and Subsets; Monocytes; T Cells |
| Purity or Quality Grade | ≥95% |
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