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Invitrogen™ IL-15/IL-15R Complex Mouse ELISA Kit

For the quantitative detection of mouse IL-15/IL-15R.

Brand:  Invitrogen™ BMS6023

301.60 GBP valid until 2020-12-18
Use promo code "14718" to get your promotional price.



Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15591987

  • £377.00 / 96 tests


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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to mouse IL-15/IL-15R
Biotin-Conjugate anti-mouse IL-15/IL-15R polyclonal antibody
Streptavidin-HRP
Mouse IL-15/IL-15R Standard lyophilized, 400pg/mL upon reconstitution
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Sample Diluent
Calibrator Diluent
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

Interleukin-15 (IL-15) is a 14 kDa proinflammatory protein that has been shown to play a role in the activation of neutrophils, dendritic cells, and macrophages, and is essential to the development and survival of NK cells and CD8 T-cells. IL-15 activates Jak/Stat pathways by signaling through a heterotrimeric receptor. Two of the subunits of this receptor, beta and gamma, are shared with the IL-2 receptor, while the alpha subunit is unique to IL-15.Despite the expression of IL-15 mRNA in many cell types, the secreted protein is rarely detectable in biological samples. Recent research suggests that IL-15 is retained inside the cell and is only secreted in complex with its unique receptor, IL-15R alpha. This chaperoning is required from the ER to Golgi through to secretion. The cytokine/receptor complex may stay bound to the cell surface, where it can be trans-presented to cells expressing the beta/gamma subunits of the receptor, or may be secreted in a soluble form that lacks the transmembrane domain of the receptor. The soluble IL-15/IL-15R complex is produced by mouse dendritic cells, fibroblasts, and macrophages, and demonstrates a 10-100-fold increase in agonistic activity over IL-15 alone.
Specifications

Specifications

P48346,Q60819
Biotin
16168, 16169
ELISA Kit
2.0 pg/mL
Plasma, 50 μL|Serum, 50 μL|Supernatant, 50 μL
1 hr. 20 min.
Mouse
Interleukin 15, Interleukin 15 Receptor
5.3%
Mouse
HRP
6.3-400 pg/mL
ELISA
Pre-coated 96 well plate, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
RUO
50 μL
2°C to 8°C
3 hr. 30 min.
AA690181,IL-15RA,AI503618,IL-15
6.3%
96 Tests
Supernatant
Colorimetric Microplate Reader
Vidéos
Documents

For Research Use Only