Gibco™ Mouse IL-12 p80 Recombinant Protein, PeproTech®

Product Code. 17821523

Brand: Gibco™ 21012P80H250UG

Description

Recombinant Protein

210-12P80H-100UG will be provided as 2 x 50 μg (210-12P80H-50UG). 210-12P80H-1MG will be provided as 20 x 50 μg (210-12P80H-50UG). 210-12P80H-250UG will be provided as 5 x 50 μg (210-12P80H-50UG). 210-12P80H-500UG will be provided as 5 x 100 μg (210-12P80H-50UG). Recombinant Murine IL-12 p80 is an 80.0 kDa, disulfide linked homodimer of two p40 chains of IL-12 that consists of 626 amino acid residues and less than 5% of the IL-12 p40 monomer. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicates that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or it can form the homodimer designated IL-12 p80. Elevated levels of IL-12 p80 correlate to macrophage recruitment and increased inflammation in asthma and respiratory viral infection models.

Specifications

• Accession Number: P43432
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 16160
• Molecular Weight (g/mol): 80
• Name: Mouse IL-12 p80
• Quantity: 5 x 50 μg
• Source: HEK293 cells
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: IL-12
• Gene Symbol: IL12B
• Specific Reactivity: Mouse
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: p40 subunit: MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS
• Form: Lyophilized
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.