eBioscience™ Human Glial Cell Derived Neurotrophic Factor (GDNF), Recombinant Protein

Human Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-8506-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15597536

Quantity Price
1 £ 176.7 / 25µg
Estimated Shipment date
from Supplier 02-06-2017
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Description and Specification

Specification

Molecular Weight 30kDa (homodimer)
Purification Method SDS-PAGE
Source E. coli
Storage Requirements Store at less than or equal to -70°C.
Quantity 25μg
For Use With (Application) Cytokine Bioassays
Formulation Sterile liquid; 10mM phosphate buffer, 150mM NaCl, 1.0% BSA. 0.22μm filtered.
Product Type Recombinant Protein
Recombinant Yes
Name Glial Cell Derived Neurotrophic Factor (GDNF)
Conjugate Unlabeled
Structural Form E. coli expressed amino acids Ser78 - Ile211 Accession # CAG46721
Biological Activity The ED50 , calculated by dose-dependent induction of rat C6 cell proliferation, is 1ug/mL, corresponding to a specific activity of 1x103 units/mg.
Purity >98%
Cross Reactivity Human
Endotoxin Concentration Less than 0.01ng/μg cytokine as determined by the LAL assay.
Regulatory Status RUO

Glial Cell derived Neurotrophic Factor (GDNF), a member of the TGFß superfamily, is a neurotrophic factor that promotes the survival of various neuronal populations in both the central and peripheral nervous systems during their development. Neuronal subpopulations affected by GDNF include motor neurons, midbrain dopaminergic neurons and Purkinje cells. GDNF is conserved across mammalian species with human and rat orthologs sharing approximately 93% amino acid sequence identity. E. coli-produced recombinant human GDNF is a disulfide-linked, non-glycosylated homodimer composed of two 135 amino acid polypeptides.