STAT5A, Mouse, Clone: M148, Abnova™

Mouse monoclonal antibody raised against synthetic phosphopeptide of STAT5A.

Brand:  Abnova MAB1375.100uL

Product Code. 16092276

Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq

Specifications

• Antigen: STAT5A
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:2000) Western Blot (1:500) The optimal working dilution should be determined by the end user.
• Gene: STAT5A
• Gene Symbols: STAT5A
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y694 of human STAT5A.
• Regulatory Status: RUO
• Gene ID (Entrez): 6776
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1

• Applications: ELISA, Western Blot
• Clone: M148
• Description: Mouse monoclonal antibody raised against synthetic phosphopeptide of STAT5A.
• Formulation: In PBS (50% glycerol, 1mg/mL BSA, 0.05% sodium azide)
• Gene Alias: MGF/STAT5
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: This peptide sequence is identical to tyrosine 699 in human Stat5B, and has high homology to the conserved tyrosine site in rat and mouse Stat5A/B.
• Form: Liquid