RARA, Mouse, Clone: 763, Abnova™

Mouse monoclonal antibody raised against synthetic peptide of RARA.

Brand:  Abnova MAB1779.100uL

Product Code. 16075066

Description

Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).[supplied by OMIM

Specifications

• Antigen: RARA
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Western Blot (1:1000) The optimal working dilution should be determined by the end user.
• Gene: RARA
• Gene Symbols: RARA
• Immunogen: A synthetic peptide corresponding to N-terminus human RARA.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: Specific for the ∼48k RARB isotype.
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1

• Applications: Western Blot
• Clone: 763
• Description: Mouse monoclonal antibody raised against synthetic peptide of RARA.
• Formulation: In 10mM HEPES, 150mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
• Gene Alias: NR1B1/RAR
• Host Species: Mouse
• Purification Method: Protein G purification
• Regulatory Status: RUO
• Gene ID (Entrez): 5914
• Target Species: Human
• Form: Liquid