PTEN, Mouse, Clone: 1B8, Abnova™

Mouse monoclonal antibody raised against recombinant PTEN.

Brand:  Abnova MAB10405.100uL

Product Code. 16020186

Description

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq

Specifications

• Antigen: PTEN
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000) Western Blot (1:500-1:2000) Immunofluorescence (1:200-1:1000) Flow cytometry (1:200-1:400) The optimal working dilution should be determined by the end user.
• Gene: PTEN
• Gene Symbols: PTEN
• Immunogen: Recombinant protein corresponding to human PTEN.
• Regulatory Status: RUO
• Gene ID (Entrez): 5728
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Immunofluorescence, Western Blot
• Clone: 1B8
• Description: Mouse monoclonal antibody raised against recombinant PTEN.
• Formulation: In PBS (50% glycerol, 0.03% sodium azide)
• Gene Alias: 10q23del/BZS/MGC11227/MHAM/MMAC1/PTEN1/TEP1
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Form: Liquid