PSMB8, Mouse, Clone: 1A5, Abnova™

Mouse monoclonal antibody raised against recombinant PSMB8.

Brand:  Abnova MAB10306.100uL

Product Code. 16060086

Description

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 nonidentical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a nonlysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq

Specifications

• Antigen: PSMB8
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000) Western Blot (1:500-1:2000) Immunohistochemistry (1:200-1:1000) Immunofluorescence (1:200-1:1000) The optimal working dilution should be determined by the end user.
• Gene: PSMB8
• Gene Symbols: PSMB8
• Immunogen: Recombinant protein corresponding to human PSMB8.
• Regulatory Status: RUO
• Gene ID (Entrez): 5696
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1

• Applications: ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
• Clone: 1A5
• Description: Mouse monoclonal antibody raised against recombinant PSMB8.
• Formulation: In ascites (0.03% sodium azide)
• Gene Alias: D6S216/D6S216E/LMP7/MGC1491/PSMB5i/RING10/beta5i
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid