PPM1A, Mouse, Monoclonal Antibody, Abnova™

Mouse monoclonal antibody raised against partial recombinant protein of PPM1A.

Brand:  Abnova MAB11157.50ug

Product Code. 16060626

Description

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq

Specifications

• Antigen: PPM1A
• Classification: Monoclonal
• Description: Mouse monoclonal antibody raised against partial recombinant protein of PPM1A.
• Formulation: In PBS, pH 7.4 (1% BSA, 50% glycerol, 0.02% sodium azide)
• Gene Alias: FLJ42306/MGC9201/PP2C-ALPHA/PP2CA
• Host Species: Mouse
• Purification Method: Protein G purification
• Regulatory Status: RUO
• Gene ID (Entrez): 5494
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Dilution: ELISA (1:5000-1:20000) Western Blot (1:100-1:2000) The optimal working dilution should be determined by the end user.
• Gene: PPM1A
• Gene Symbols: PPM1A
• Immunogen: Recombinant protein corresponding to N-terminus of human PPM1A.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid