MMP13, Mouse, Clone: M66, Abnova™

Mouse monoclonal antibody raised against recombinant MMP13.

Brand:  Abnova MAB10000.100ug

Product Code. 16069975

Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq

Specifications

• Antigen: MMP13
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:2000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:2000) The optimal working dilution should be determined by the end user.
• Gene: MMP13
• Gene Symbols: MMP13
• Immunogen: Recombinant protein corresponding to human MMP13.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: Based on ELISA, the antibody reacts with human procollagenase-3. The antibody does not cross react with MT1-MMP latent form (MMP14), MT2-MMP cat. domain (MMP15), MT3-MMP cat. domain (MMP16), MT4-MMP cat. domain (MMP17), MT5-MMP cat. domain (MMP18), Gelatinase A (MMP2) latent form, Gelatinase B (MMP9) latent form, Collagenase 2 (MMP8) latent form.
• Content And Storage: Store at -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry (PFA fixed)
• Clone: M66
• Description: Mouse monoclonal antibody raised against recombinant MMP13.
• Formulation: In 20mM Na-phosphate, 150mM NaCl, pH 7.5 (0.01% thimerosal)
• Gene Alias: CLG3
• Host Species: Mouse
• Purification Method: Protein G purification
• Regulatory Status: RUO
• Gene ID (Entrez): 4322
• Target Species: Human
• Form: Liquid