LBP, Mouse, Clone: biG 42, Abnova™

Mouse monoclonal antibody raised against recombinant LBP.

Brand:  Abnova MAB5661.100ug

Product Code. 16241000

Description

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene. [provided by RefSeq

Specifications

• Antigen: LBP
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000) The optimal working dilution should be determined by the end user.
• Gene: LBP
• Gene Symbols: LBP
• Immunogen: Recombinant protein corresponding to human LBP.
• Regulatory Status: RUO
• Gene ID (Entrez): 3929
• Target Species: Human
• Form: Lyophilized

• Applications: ELISA, Western Blot
• Clone: biG 42
• Description: Mouse monoclonal antibody raised against recombinant LBP.
• Formulation: Lyophilized from PBS
• Gene Alias: MGC22233
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: LPS binding protein (LBP) is an approximately 60 KDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to a 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.
• Content And Storage: Store at -20°C on dry atmosphere. After reconstitution with deionized water store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1