KIR2DL4, Mouse, Clone: mAb33, Abnova™

Mouse monoclonal antibody raised against KIR2DL4.

Brand:  Abnova MAB10178.100ug

Product Code. 16050026

Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the framework loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Specifications

• Antigen: KIR2DL4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Flow Cytometry (1 ug/ml) The optimal working dilution should be determined by the end user.
• Gene: KIR2DL4
• Gene Symbols: KIR2DL4
• Immunogen: NK3.3 cells and human KIR2DL4-Ig fusion protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

• Applications: Flow Cytometry, Functional Assay, Immunocytochemistry, Immunoprecipitation, Western Blot
• Clone: mAb#33
• Description: Mouse monoclonal antibody raised against KIR2DL4.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene Alias: CD158D/G9P/KIR103/KIR103AS
• Host Species: Mouse
• Purification Method: Protein A purification
• Regulatory Status: RUO
• Gene ID (Entrez): 3805
• Content And Storage: Store at 4°C. Do not freeze.
  Avoid repeated freezing and thawing.
• Isotype: IgG1