CDKN2A, Mouse, Clone: 5A8A4, 3G8D12, Abnova™

Mouse monoclonal antibody raised against partial recombinant CDKN2A.

Brand:  Abnova MAB8309.100uL

Product Code. 16141080

Description

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq

Specifications

• Antigen: CDKN2A
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Western Blot (1:500-1:2000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:1000) ELISA (1:10000) The optimal working dilution should be determined by the end user.
• Gene: CDKN2A
• Gene Symbols: CDKN2A
• Immunogen: Recombinant protein corresponding to truncated human CDKN2A.
• Regulatory Status: RUO
• Gene ID (Entrez): 1029
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: ELISA, Immunohistochemistry, Western Blot
• Clone: 3G8D12, 5A8A4
• Description: Mouse monoclonal antibody raised against partial recombinant CDKN2A.
• Formulation: In ascites
• Gene Alias: ARF/CDK4I/CDKN2/CMM2/INK4/INK4a/MLM/MTS1/TP16/p14/p14ARF/p16/p16INK4/p16INK4a/p19
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid