CD92 Mouse anti-Human, Alexa Fluor 647, Clone: VIM15, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 565316

Product Code. 15804239

Description

The VIM15 monoclonal antibody specifically binds to CD92 which is also known as Solute carrier family 44 member 1 (SLC44A1), or Choline transporter-like protein 1 (CHTL1). CD92 is a multipass membrane glycoprotein that belongs to the choline transporter-like family. It contains a tyrosine-based inhibitory motif (ITIM) in its cytoplasmic C-terminus. CD92 appears to be involved in choline transport for cell membrane phospholipid synthesis and in regulatory cell-signaling pathways. CD92 is strongly expressed by monocytes and at lower levels by granulocytes and some dendritic cells. It is generally expressed at low levels by B cells, endothelial cells, epithelial cells, and subsets of T cells, or NK cells. The VIM15 antibody has been shown to augment lipopolysaccharide-induced IL-10 production by monocyte-derived dendritic cells (Mo-DC). When cultured with ionomycin or calcium ionophore, maturing Mo-DC showed downregulation of CD92 expression.

Specifications

• Antigen: CD92
• Classification: Monoclonal
• Conjugate: Alexa Fluor 647
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: Human Myeloid Cell Line MV4-11
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: VIM15
• Description: SLC44A1; Choline transporter-like protein 1; CHTL1; CTL1; RP11-287A8.1; p70
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ