BRCA1, Mouse, Clone: RAY, Abnova™

Mouse monoclonal antibody raised against partial recombinant BRCA1.

Brand:  Abnova MAB2362.100uL

Product Code. 16055606

Description

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq

Specifications

• Antigen: BRCA1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Immunocytochemistry (1:100) Western Blot (2-4 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: BRCA1
• Gene Symbols: BRCA1
• Immunogen: Recombinant protein corresponding to amino acids 1314-1864 of human BRCA1.
• Regulatory Status: RUO
• Gene ID (Entrez): 672
• Target Species: Human
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Clone: RAY
• Description: Mouse monoclonal antibody raised against partial recombinant BRCA1.
• Formulation: In PBS (0.09% sodium azide)
• Gene Alias: BRCAI/BRCC1/IRIS/PSCP/RNF53
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: This antibody recognizes the epitope aa 1314-1600.
• Content And Storage: Store at -20°C or -80°C.
  Aliquot to avoid repeated freezing and thawing.