Invitrogen™ MMRN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Marca:  Invitrogen™ PA557392

Código de producto. 15725291

Descripción

Immunogen sequence: RHNLLRNEVQ GRDDALERRI NEYALEMEDG LNKTMTIINN AIDFIQDNYA LKETLSTIKD NSEIHHKCTS DMETILTFIP QFHRLND Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 63%.

Multimerin-1, also known as MMRN1, EMILIN-4 or ECM (endothelial cell multimerin), is a 1,228 amino acid secreted protein that contains one C1q domain, one EMI domain and one EGF-like domain. Synthesized in megakaryocytes and endothelial cells and present in liver, lung and placenta, Multimerin-1 exists as a multimeric structure composed of varying disulfide-linked multimers and functions as a carrier protein for platelet factors (specifically platelet factor V), playing a role in the stabilization and storage of factor V in platelets. In addition, Multimerin-1 acts as a ligand for select Integrins and may participate in extracellular matrix adhesion. Defects in the gene encoding Multimerin-1 that lead to Multimerin-1 deficiency are associated with autosomal dominant bleeding disorders due to platelet factor malfunction. Multiple isoforms of Multimerin-1 exist due to alternative splicing events.

Especificaciones

• Antigen: MMRN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MMRN1
• Gene Alias: 155 kDa platelet multimerin; 4921530G03Rik; ECM; Elastin microfibril interface located protein 4; elastin microfibril interfacer 4; EMILIN4; EMILIN-4; Endothelial cell multimerin; glycoprotein Ia*; GPIa*; MMRN; mmrn1; multimerin 1; multimerin-1; p155; p-155; Platelet glycoprotein Ia*
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22915
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q13201
• Gene Symbols: MMRN1
• Immunogen: Recombinant protein corresponding to Human MMRN1. Recombinant protein control fragment (Product #RP-96663).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG