Invitrogen™ MMP23 (Cleaved Tyr79) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA537434

Product Code. 15554391

Description

This antibody detects endogenous protein at a molecular weight of 37 and 44 kDa. Purity is >95% by SDS-PAGE.

Matrix metalloproteinases (MMPs) are highly homologous Zn2+ endopeptidases involved in extracellular matrix breakdown. MMP mediated extracellular remodeling occurs in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, including arthritis and metastasis. MMP-23 exhibits sequence similarity with most MMPs, but displays a difference in domain structure. The MMP-23 protein contains prepro-, catalytic, cysteine-rich, Interleukin-1 receptor-related and proline-rich domains. Lacking a recognizable signal sequence, MMP-23 has a short prodomain. In addition, MMP-23 contains a single cysteine residue that can be part of the cysteine-switch mechanism operation for maintaining enzyme latency. MMP-23 is a membrane-anchored glycoprotein with type II topology. Subcellular localization is predominantly perinuclear.

Specifications

• Antigen: MMP23 (Cleaved Tyr79)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MMP23B
• Gene Alias: Femalysin; matrix metallopeptidase 23A (pseudogene); matrix metallopeptidase 23B; matrix metalloproteinase 22; matrix metalloproteinase 23B; matrix metalloproteinase in the female reproductive tract; matrix metalloproteinase-21; Matrix metalloproteinase-22; matrix metalloproteinase-23; Matrix metalloproteinase-23, soluble form; MIFR; MIFR-1; MMP 23; MMP21; MMP-21; MMP22; MMP-22; MMP23; MMP-23; MMP23A; MMP23B; soluble form
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8510, 8511
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O75900
• Gene Symbols: MMP23B
• Immunogen: Synthetic peptide corresponding to amino acids 51-100 of human MMP-23.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG