Invitrogen™ MMP15 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA575175

Product Code. 15921705

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastasis.

Specifications

• Antigen: MMP15
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mmp15
• Gene Alias: AI503551; matrix metallo protease; matrix metallopeptidase 15; matrix metallopeptidase 15 (membrane-inserted); matrix metalloproteinase 15; matrix metalloproteinase 15 (membrane-inserted); matrix metalloproteinase-15; Membrane type 2-MMP; membrane-type matrix metalloproteinase 2; Membrane-type-2 matrix metalloproteinase; MMP; Mmp15; MMP-15; MMPs; MT2MMP; MT2-MMP; MT-MMP 2; MTMMP2; SMCP-2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17388, 291848, 4324
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide; pH 7.2
• Gene Accession No.: O54732, P51511
• Gene Symbols: Mmp15
• Immunogen: Synthetic peptide corresponding to amino acids 621-669 of Human MMP-15.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG