MMP12 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16822155	Proteintech 22989-1-AP-20UL	20 μL
16812155	Proteintech 22989-1-AP-150UL	150 μL

Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP′s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Specifications

• Antigen: MMP12
• Applications: Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: P34960, P39900
• Gene ID (Entrez): 17381, 4321
• Immunogen: MMP12 Fusion Protein Ag19068
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: MMP12

• Concentration: 0.52 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: HME, Macrophage elastase, Macrophage metalloelastase, Matrix metalloproteinase 12, ME, MME, MMP 12, MMP12
• Gene Symbols: Mmp12
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody