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Tocris Bioscience™ MLN 4924
Potent and selective NEDD8 activating enzyme (NAE) inhibitor; cell permeable
£138.23 - £528.06
Specifications
Chemical Name or Material | [(1 S,2 S,4 R)-4-[4-[[(1 S)-2,3-Dihydro-1 H-inden-1-yl]amino]-7 H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamic acid ester |
---|---|
CAS | 905579-51-3 |
Target | NEDD8 Activating Enzyme E1) |
Molecular Formula | C21H25N5O4S |
Purity | 0.98 |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
18779236
|
Tocris Bioscience™
6499/10 |
10 mg |
£138.23
10mg |
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18785656
|
Tocris Bioscience™
6499/50 |
50 mg |
£528.06
50mg |
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Description
MLN 4924 (Tak 924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50 = 4.7 nM). MLN 4924 exhibits selectivity over closely related enzymes UAE, UBA6, SAE, and ATG7 (IC50 = 1.5, 1.8, 8.2, and >10 μM, respectively), and displays minimal activity at adenosine receptors and a panel of 12 cellular kinases. MLN 4924 exhibits cyotoxicity in several human tumor-derived cell lines and causes liver damage in SD rats, when given with TNF-α. It blocks the NEDD8 pathway causing DNA damage in mice bearing HCT-116 xenografts. Cell permeable.Specifications
[(1 S,2 S,4 R)-4-[4-[[(1 S)-2,3-Dihydro-1 H-inden-1-yl]amino]-7 H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamic acid ester | |
NEDD8 Activating Enzyme E1) | |
0.98 |
905579-51-3 | |
C21H25N5O4S |
Safety and Handling
Recommended Storage : Store at -20°C