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Tocris Bioscience™ MLN 4924

Potent and selective NEDD8 activating enzyme (NAE) inhibitor; cell permeable

£138.23 - £528.06

Specifications

Chemical Name or Material [(1 S,2 S,4 R)-4-[4-[[(1 S)-2,3-Dihydro-1 H-inden-1-yl]amino]-7 H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamic acid ester
CAS 905579-51-3
Target NEDD8 Activating Enzyme E1)
Molecular Formula C21H25N5O4S
Purity 0.98
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Tocris Bioscience™
6499/10
10 mg
£138.23
10mg
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Tocris Bioscience™
6499/50
50 mg
£528.06
50mg
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Estimated Shipment: 29-07-2024
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Description

Description

MLN 4924 (Tak 924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50 = 4.7 nM). MLN 4924 exhibits selectivity over closely related enzymes UAE, UBA6, SAE, and ATG7 (IC50 = 1.5, 1.8, 8.2, and >10 μM, respectively), and displays minimal activity at adenosine receptors and a panel of 12 cellular kinases. MLN 4924 exhibits cyotoxicity in several human tumor-derived cell lines and causes liver damage in SD rats, when given with TNF-α. It blocks the NEDD8 pathway causing DNA damage in mice bearing HCT-116 xenografts. Cell permeable.
Specifications

Specifications

[(1 S,2 S,4 R)-4-[4-[[(1 S)-2,3-Dihydro-1 H-inden-1-yl]amino]-7 H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamic acid ester
NEDD8 Activating Enzyme E1)
0.98
905579-51-3
C21H25N5O4S
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