Invitrogen™ MLK4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA599276

Product Code. 16663525

Description

Antibody detects endogenous levels of total MLK4.

MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas. MLK4 is a negative regulator of TLR4 and does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

Specifications

• Antigen: MLK4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP3K21
• Gene Alias: BC021891; cDNA sequence BC021891; dJ862P8.3; Kiaa1804; MAP3K21; Mitogen-activated protein kinase kinase kinase 21; Mitogen-activated protein kinase kinase kinase MLK4; mixed lineage kinase 4; mKIAA1804; MLK4; RGD1306091; similar to Mixed lineage kinase 4
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84451
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q5TCX8
• Gene Symbols: MAP3K21
• Immunogen: A synthesized peptide derived from human MAP3K21(Accession Q5TCX8), corresponding to amino acid residues S862-A912.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG