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ML347, MedChemExpress

Product Code. 16485048
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Product Code. 16485048 Supplier Medchem Express Supplier No. HY12274

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Description

MedChemExpress ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1.

ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1.

Specifications

Chemical Name or Material ML347
CAS 1062368-49-3
Color Yellow
Purity Grade Notes Research
Molecular Formula C22H16N4O
Quantity 10 mg
Synonym LDN 193719
Solubility Information DMSO : 10 mg/mL (28.38 mM; Need ultrasonic)
SMILES COC1=CC=C(C2=CN3C(N=C2)=C(C4=C5C=CC=NC5=CC=C4)C=N3)C=C1
Molecular Weight (g/mol) 352.39
Formula Weight 352.39
Percent Purity 99.85%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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