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  4. Invitrogen™ Human MKNK1 (MNK1), GST Tag Recombinant Protein

Invitrogen™ Human MKNK1 (MNK1), GST Tag Recombinant Protein

Product Code. 10600930
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Quantity:
10 μg
Unit Size:
Each
This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Product Code. 10600930

Brand: Invitrogen™ PV6023

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Full Length.

The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases, regulate protein synthesis by phosphroylation eIF4E on Ser209, and may contribute to tumorigenesis. Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94% identical) and human Mnk1 (71% identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9BUB5
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM tris with no preservative
Gene ID (Entrez) 8569
Molecular Weight (g/mol) 66.6 kDa
Name Human MKNK1 (MNK1), GST Tag
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias 2410048M24Rik; MAP kinase interacting serine/threonine kinase 1; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal-integrating kinase 1; MKNK1; Mnk1; OTTHUMP00000009675; OTTHUMP00000009676
Common Name MNK1
Gene Symbol MKNK1
KinaseFamily MAPKAPK Kinase Family
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Sequence Full length
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Kinase Group Ser⁄Thr Kinases: CAMK Group
Shipping Condition Dry Ice
Tag Position N-Terminal
Target Gene MKNK1
Expression System Insect cells
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Full Length
Form Liquid
Protein Subtype Serine/Threonine Kinases
Research Category Signal Transduction
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