Invitrogen™ MKL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5103370

Product Code. 16619824

Description

Antibody detects endogenous levels of total MKL2.

Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factors A and B (MRTF-A and MRTF-B) interact with SRF and act as stimulators for its transcriptional activity. MRTF-B is crucial for skeletal myogenic differentiation.

Specifications

• Antigen: MKL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mkl2
• Gene Alias: CTA-276F8.1; ENSMUSG00000075401; gene trap insertion site 4-1; Gt4-1; KIAA1243; Megakaryoblastic leukemia 2; megakaryoblastic leukemia 2 protein; mKIAA1243; MKL/myocardin like 2; MKL/myocardin-like 2; MKL/myocardin-like protein 2; MKL1/myocardin like 2; Mkl2; Mrtfb; MRTF-B; myocardin related transcription factor B; myocardin-related transcription factor B; myocardin-related transcription factor B; MKL/myocardin-like protein 2; NPD001; RGD1560833
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 239719, 57496
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P59759, Q9ULH7
• Gene Symbols: Mkl2
• Immunogen: A synthesized peptide derived from human MKL2(Accession Q9ULH7), corresponding to amino acid residues A605-S655.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG