MK-0752, MedChemExpress

Product Code. 16407047

Brand: Medchem Express HY10974

Description

MedChemExpress MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo.

MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo.

Specifications

• Chemical Name or Material: MK-0752
• CAS: 471905-41-6
• Color: White
• Purity Grade Notes: Research
• Molecular Formula: C₂₁H₂₁ClF₂O₄S
• Quantity: 5 mg
• Solubility Information: DMSO : ≥ 100 mg/mL (225.78 mM) ∣Ethanol : 10 mg/mL (22.58 mM; Need ultrasonic)
• SMILES: O=S([C@@]1(C2=C(C=CC(F)=C2)F)CC[C@@H](CCC(O)=O)CC1)(C3=CC=C(Cl)C=C3)=O
• Molecular Weight (g/mol): 442.9
• Formula Weight: 442.9
• Percent Purity: 95.0%
• Grade: Research
• Physical Form: Solid
• For Use With (Application): Cancer-programmed cell death

Research purposes only