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STEMCELL Technologies Mitomycin C

Product Code. 17190192
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 17190192

Brand: STEMCELL Technologies 73274

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This item is not returnable. View return policy

Description

Antibiotic; Double-stranded DNA alkylating agent

  • Mitomycin C is an antibiotic which acts as a double-stranded DNA alkylating agent
  • It covalently crosslinks DNA, inhibiting DNA synthesis and cell proliferation
  • It acts by way of reductive activation either through low pH or NAD(P)H:quinone oxidoreductase (DT-diaphorase) or NADH cytochrome c reductase (Mao et al.; Cummings et al.)
  • Mitotically inactivates mouse embryonic fibroblasts (MEFs) for use as feeder cell layers in embryonic stem cell co-culture systems (Bryja et al.)
  • Selectively inhibits DNA synthesis and mutagenesis, stimulates genetic recombination, chromosome breakage and sister chromatid exchange, and induces DNA repair (Tomasz)

Specifications

CAS 50-07-7
Quantity 10 mg
Percent Purity ≥98%
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