Invitrogen™ MIP-3 beta Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA584767

Product Code. 16371715

Description

Immunogen sequence: LLIKDGCRVP AVVFTTLRGR QLCAPPDQPW VERIIQRLQR TSAKMKRRSS Highest antigen sequence indentity to the following orthologs: Rat - 76%, Mouse - 76%.

CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC- subfamily of chemokines. It is most closely related to CCL21, with which it shares 32% amino acid sequence homology. CCL19 and CCL21 are expressed mainly by stromal cells in the T cell-rich zones of lymph nodes. They are critical mediators of the homeostatic trafficking of naive T cells and activated dendritic cells into the secondary lymphoid organs. CCL19 and CCL21 also play a role in T cell priming and activation, as well as the recruitment of lymphocytes to inflamed tissue. Both proteins signal via the G protein-coupled receptor, CCR7, which is expressed on T cells and mature dendritic cells. Although CCL19 and CCL21 both exhibit the same affinity for CCR7, only the binding of CCL19 results in the desensitization and internalization of the receptor.

Specifications

• Antigen: MIP-3 beta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ccl19
• Gene Alias: beta chemokine exodus-3; beta-chemokine exodus-3; CC chemokine ligand 19; C-C motif chemokine; C-C motif chemokine 19; C-C motif chemokine ligand 19; Ccl19; chemokine (C-C motif) ligand 19; chemokine CCL19; CK beta-11; CKb11; EBI1 ligand chemokine; EBI-1 ligand chemokine; EBI1-ligand chemokine; EBV-induced molecule 1 ligand chemokine; ELC; Epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; MIP3B; MIP-3b; MIP-3-beta; M-MIP-3-beta; SCYA19; small inducible cytokine A19; small inducible cytokine subfamily A (Cys-Cys), member 19; small-inducible cytokine A19
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6363
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q99731
• Gene Symbols: Ccl19
• Immunogen: Recombinant protein corresponding to Human CCL19. Recombinant protein control fragment (Product #RP-107597).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG