MICAL3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA565130

Product Code. 15907904

Description

Immunogen sequence: MELASGAPRPR KASSAPSQGK ERRPDSPTRP TLRGSEEPTL KHEATSEEVL SPPSDSGGPD GSFTSSEGSS GKSKKRSSLF SPRRNKKEKK Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 75%.

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. [UniProt]

Specifications

• Antigen: MICAL3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MICAL3
• Gene Alias: [F-actin]-monooxygenase MICAL3; flavoprotein oxidoreductase MICAL3; KIAA0819; KIAA1364; MICAL3; MICAL-3; microtubule associated monooxygenase, calponin and LIM domain containing 3; molecule interacting with CasL protein 3; protein MICAL-3; protein-methionine sulfoxide oxidase MICAL3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57553
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q7RTP6
• Gene Symbols: MICAL3
• Immunogen: Recombinant Human MICAL3
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

For Research Use Only