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Invitrogen™ MICA Polyclonal Antibody

Product Code. 12808582
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Quantity:
100 μg
Unit Size:
100µg
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12808582 100 μg 100µg
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Product Code. 12808582 Supplier Invitrogen™ Supplier No. PA520393

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Description

Rabbit Polyclonal Antibody

A suggested positive control is A549 cell lysate. PA5-20393 can be used with blocking peptide PEP-0510.

Major histocompatibility complex (MHC) class I proteins are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. A related family, termed the MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. Both MICA and MICB mRNA are widely expressed in normal tissues, with MICA being present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MICA
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene MICA
Gene Accession No. Q29983
Gene Alias DAMA-345G11.2; HLA class I antigen; MHC class I chain-related protein A; MHC class I polypeptide-related sequence A; MHC class I related sequence A; MICA; MIC-A; PERB11.1; stress inducible class I homolog; truncated MHC class I polypeptide-related sequence A
Gene Symbols MICA
Host Species Rabbit
Immunogen A 16 amino acid peptide from near the carboxy terminus of human MICA.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100507436
Target Species Human, Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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