MIB1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11893-1-AP-20UL

Product Code. 16899263

Description

MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

Specifications

• Antigen: MIB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MIB1
• Gene Alias: DAPK interacting protein 1, DIP 1, DIP1, KIAA1323, MIB, MIB1, Mind bomb homolog 1, ZZANK2, ZZZ6
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57534
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunoprecipitation, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.23 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q86YT6
• Gene Symbols: MIB1
• Immunogen: MIB1 Fusion Protein Ag2507
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG