Methotrexate, Fisher BioReagents

Product Code. 10705304

Brand: Fisher BioReagents BP266510

Description

• Inhibitor of DNA and RNA synthesis
• Inhibits the enzyme responsible for synthesizing the folic acid derivative that is necessary for purine and pyrimidine synthesis
• The lack of purines and pyrimidines  impacts the synthesis of DNA, RNA, and proteins
• Referenced for use in antitumor studies and other studies of biological pathways
• Intended for research use only

Specifications

Chemical Identifiers

• CAS: 59-05-2
• Molecular Formula: C20H22N8O5
• Molecular Weight (g/mol): 454.447
• InChI Key: FBOZXECLQNJBKD-ZDUSSCGKSA-N
• Synonym: methotrexate, abitrexate, rheumatrex, amethopterin, mexate, metatrexan, hdmtx, trexall, methylaminopterinum, antifolan
• PubChem CID: 126941
• ChEBI: CHEBI:44185
• IUPAC Name: (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
• SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

• Decomposition Information: >195°C
• Melting Point: 195°C
• Color: Yellow
• Ignition Residue: 0.1% max.
• Assay Percent Range: 98.0 to 102.0 %
• Packaging: Amber Glass
• Quantity: 10 mg
• Merck Index: 15, 6057
• Specific Rotation: +19.0 to +24.0° (+ or -)
• Formula Weight: 454.44
• Percent Purity: 98.0 to 102.0%
• Physical Form: Powder or Solid
• Chemical Name or Material: Methotrexate

Safety and Handling

Product Identifier

• Methotrexate

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 3
• Serious eye damage/eye irritation Category 2
• Germ cell mutagenicity Category 1B
• Reproductive toxicity Category 1B
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H340-May cause genetic defects.
• H360FD-May damage fertility. May damage the unborn child.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.
• H301-Toxic if swallowed.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

SDS