Methotrexate disodium salt, 98.5%

Product Code.	Quantity	Unit Size
15467689	250 mg	250mg

Product Code. 15467689 Supplier Thermo Scientific Alfa Aesar Supplier No. J66364.MD

Description

Methotrexate disodium salt, CAS # 7413-34-5, is the sodium salt of methotrexate that shows antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities. | CAS: 7413-34-5 | C20H20N8Na2O5 | 498.411 g/mol

Inhibits the metabolism of folic acid

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Methotrexate disodium salt is an organic sodium salt derived from methotrexate with antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities

• It acts as an enzyme inhibitor of dihydrofolate reductase

• It binds to and inhibits purine nucleotide and thymidylate synthesis, leading to the inhibition of DNA and RNA synthesis. Because of this mechanism of action, the methotrexate disodium salt is defined as a nucleic acid synthesis inhibitor

Application

• Methotrexate disodium salt is a folic acid antagonist with the ability to inhibit folic acid metabolism

• In vitro studies demonstrated that methotrexate disodium salt has potent activity against pyrimethamine-resistant Plasmodium vivax malaria parasites

• This compound has been used in chimeric polymersomes in order to investigate its effect in lung tumor xenografts in mice

Specifications

• CAS: 7413-34-5
• Color: Yellow
• Boiling Point: 823°C
• Molecular Formula: C20H20N8Na2O5
• MDL Number: MFCD00274560
• Quantity: 250 mg
• UN Number: UN2811
• Sensitivity: Hygroscopic
• Synonym: methotrexate disodium salt, sodium methotrexate, ledertrexate, methotrexate sodium, mtx disodium, methotrexate disodium, unii-3ig1e710zn, trexall, mexate, methotrexate lpf
• Solubility Information: Soluble in water
• InChI Key: DASQOOZCTWOQPA-GXKRWWSZSA-L
• SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
• IUPAC Name: disodium;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
• Molecular Weight (g/mol): 498.411
• PubChem CID: 11329481
• ChEBI: CHEBI:50679
• Formula Weight: 498.4
• Percent Purity: 98.5%
• Physical Form: Powder
• Chemical Name or Material: Methotrexate disodium salt

Safety and Handling

Product Identifier

• Methotrexate disodium salt

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 3
• Serious eye damage/eye irritation Category 2
• Germ cell mutagenicity Category 1B
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H301-Toxic if swallowed.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.
• H340-May cause genetic defects.
• H360FD-May damage fertility. May damage the unborn child.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contain: Disodium N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate

SDS

RUO – Research Use Only