Invitrogen™ Metadherin Monoclonal Antibody (2F11C3)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA515564

Product Code. 11305533

Description

MA5-15564 targets Metadherin in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human samples. The MA5-15564 immunogen is purified recombinant fragment of human Metadherin expressed in E. Coli. MA5-15564 detects Metadherin which has a predicted molecular weight of approximately 64kDa.

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Specifications

• Antigen: Metadherin
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: PBS with 0.03% sodium azide
• Gene Accession No.: Q86UE4
• Gene Symbols: MTDH
• Immunogen: Purified recombinant fragment of human Metadherin expressed in E. Coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 2F11C3
• Conjugate: Unconjugated
• Gene: MTDH
• Gene Alias: 2610103J23Rik; 3D3; 3D3/Lyric; AEG1; AEG-1; astrocyte elevated gene 1; astrocyte elevated gene-1 protein; AV353288; D8Bwg1112e; LYRIC; LYRIC/ MTDH; LYRIC/3D3; lysine-rich CEACAM1 co-isolated protein; Metadherin; metastasis adhesion protein; MTDH; Protein LYRIC
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 92140
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid