MEPCE Polyclonal Antibody, Invitrogen™

Goat Polyclonal Antibody

Brand:  Invitrogen PA518813

Product Code. 11316793

Description

This antibody is predicted to react with mouse based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 2,000.

S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). [UniProt]

Specifications

• Antigen: MEPCE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: mepce
• Gene Alias: 7SK snRNA methylphosphate capping enzyme; BCDIN3; Bicoid-interacting protein 3 homolog; bin3 homolog; bin3, bicoid-interacting 3; bin3, bicoid-interacting 3, homolog; Bipl1; D5Wsu46e; fc59f06; FLJ20257; Mepce; methylphosphate capping enzyme; si:ch211-283h6.1; wu:fc59f06; zBCDIN3
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 304361, 56257
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q7L2J0
• Gene Symbols: mepce
• Immunogen: Synthetic peptide sequence (KQQRKFQYGNYCK) corresponding to the internal amino acids of MEPCE
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG