Invitrogen™ Menin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5115569

Product Code. 17218353

Description

Antibody detects endogenous levels of total MEN1.

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

Specifications

• Antigen: Menin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MEN1
• Gene Alias: AW045611; MEAI; MEN1; Menin; menin 1; multiple endocrine neoplasia 1; multiple endocrine neoplasia I; SCG2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17283, 29417, 4221
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O00255, O88559, Q9WVR8
• Gene Symbols: MEN1
• Immunogen: A synthesized peptide derived from human MEN1(Accession O00255), corresponding to amino acid residues S183-M233.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG