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Invitrogen™ MED28 Polyclonal Antibody
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Product Code. 15755351 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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15755351 100 μL 100µL
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Product Code. 15755351 Supplier Invitrogen™ Supplier No. PA557455

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VIKEDVSELR NELQRKDALV QKHLTKLRHW QQVLEDINVQ HKKPADIPQG SLAYLEQASA NIPAPLKPT Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 96%.

The mediator complex is a multi-protein transcriptional co-activator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factor. One of the proteins in this complex is MED28, also known as Magicin. MED28 is expressed in many cell lines and tissues. It has been shown that a down-regulation of MED28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell differentiation and conversely its over-expression represses expression of SMC genes. MED28 can also form a ternary complex with Grb2 and Merlin, the neurofibromatosis 2 tumor suppressor protein, indicating that MED28 may play a role in Merlin's tumor suppressive activity. MED28 has also been recently identified as an HIV dependency factor (HDF), suggesting that MED28 may be an important drug target in HIV treatment. At least two isoforms of MED28 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MED28
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MED28
Gene Accession No. P68943, Q920D3, Q9H204
Gene Alias 1500003D12Rik; AI451633; AU045690; EG1; endothelial-derived; endothelial-derived gene 1; endothelial-derived protein 1; Fksg20; Magicin; Med28; Mediator complex subunit 28; mediator of RNA polymerase II transcription subunit 28; mediator of RNA polymerase II transcription, subunit 28 homolog; merlin and Grb2-interacting cytoskeletal protein; RGD1305875; Tumor angiogenesis marker EG-1
Gene Symbols MED28
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human MED28. Recombinant protein control fragment (Product #RP-96636).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 305391, 66999, 80306
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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