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Mdivi 1, Tocris Bioscience™

Catalog Number p-4816960
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
338967-87-6
C15H10Cl2N2O2S
353.217
NZJKEVWTYMOYOR-UHFFFAOYSA-N
mdivi-1, mdivi 1, 3-2,4-dichloro-5-methoxyphenyl-2-sulfanyl-4 3h-quinazolinone, 3-2,4-dichloro-5-methoxyphenyl-2-sulfanylidene-1h-quinazolin-4-one, 3-2,4-dichloro-5-methoxyphenyl-2,3-dihydro-2-thioxo-4 1h-quinazolinone, mdivi hplc , powder, 3-2,4-dichloro-5-methoxyphenyl-2-mercaptoquinazolin-4 3h-one, 3-2,4-dichloro-5-methoxyphenyl-2-sulfanylquinazolin-4-one, 3-2,4-dichloro-5-methoxyphenyl-2-thioxo-2,3-dihydro-4 1h-quinazolinone
3825829
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanylidene-1H-quinazolin-4-one
COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl
This item is not returnable. View return policy
338967-87-6
C15H10Cl2N2O2S
353.217
NZJKEVWTYMOYOR-UHFFFAOYSA-N
mdivi-1, mdivi 1, 3-2,4-dichloro-5-methoxyphenyl-2-sulfanyl-4 3h-quinazolinone, 3-2,4-dichloro-5-methoxyphenyl-2-sulfanylidene-1h-quinazolin-4-one, 3-2,4-dichloro-5-methoxyphenyl-2,3-dihydro-2-thioxo-4 1h-quinazolinone, mdivi hplc , powder, 3-2,4-dichloro-5-methoxyphenyl-2-mercaptoquinazolin-4 3h-one, 3-2,4-dichloro-5-methoxyphenyl-2-sulfanylquinazolin-4-one, 3-2,4-dichloro-5-methoxyphenyl-2-thioxo-2,3-dihydro-4 1h-quinazolinone
3825829
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanylidene-1H-quinazolin-4-one
COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl

Description

Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

Mdivi 1 is a selective inhibitor of dynamin GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Mdivi 1 inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. In cancer cell lines, Mdivi 1 reduces cell proliferation; in an animal model of ischemic retina Mdivi 1 treatment blocks apoptosis. In a cell model, Mdivi 1 protects against mutant huntington-induced damage and mitochondrial dysfunction. Mdivi 1 also inhibits autophagy and protects neurons from excitotoxicity.
Quantity 10 mg
Formula Weight 353.22
Percent Purity >98%
Chemical Name or Material Dynamin Inhibitors
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