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MD-2 Mouse anti-Human, Clone: 9B4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9928-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15268247

  • £152.25 / 100µg


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Disclaimers:

For Research Use Only.


Specifications

Description

The 9B4 antibody reacts with human MD-2, an approximately 30kDa molecule, which physically associates with the extracellular domain of TLR4. MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4 since in MD-2(-/-) embryonic fibroblasts, TLR4 was not able to reach the plasma membrane and predominantly resided in the Golgi apparatus, whereas TLR4 was distributed at the leading edge surface of cells in wild-type embryonic fibroblasts. MD-2(-/-) mice do not respond to LPS, do survive endotoxic shock but are susceptible to Salmonella typhimurium infection.
Description & Specifications

Specifications

MD-2
9B4
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C.
Monoclonal
Immunoprecipitation
0.5mg/mL
Purified
MD2; Toll-like Receptor
IgG1
RUO
Primary
Human