Invitrogen™ MCM10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA567218

Product Code. 15989884

Description

Immunogen sequence: REKLEEIDWVT FGVILKKVTP QSVNSGKTFS IWKLNDLRDL TQCVSLFLFG EVHKALWKTE QGTVVGILNA NPMK Highest antigen sequence identity to the following orthologs - mouse 84%, rat 88%.

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Specifications

• Antigen: MCM10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MCM10
• Gene Alias: 2410041F14Rik; AU018508; C330019M07Rik; C79164; CNA43; DNA43; homolog of yeast MCM10; hsMCM10; Mcm10; MCM10 minichromosome maintenance deficient 10; MGC126776; minichromosome maintenance 10 replication initiation factor; minichromosome maintenance complex component 10; minichromosome maintenance deficient 10; minichromosome maintenance deficient 10 (S. cerevisiae); PRO2249; Protein MCM10 homolog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55388
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q7L590
• Gene Symbols: MCM10
• Immunogen: Recombinant Human MCM10. Recombinant protein control fragment (Product #RP-105551).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG