Mcl-1 Mouse anti-Human, Mouse, Clone: LVUBKM, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9047-82

100UG Anti-Human/Mouse MCL-1 Purified

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15507576

Quantity Price
1 £ 269.3 / 100µg
Estimated Shipment date
from Supplier 22-02-2017
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Description and Specification

Specification

Applications Flow Cytometry (Intracellular Staining)
Applications Immunohistochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Storage Requirements Store at 2-8°C.
Clone LVUBKM
Concentration 0.5mg/mL
Antigen Mcl-1
Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias myeloid cell leukemia sequence 1
Host Species Mouse
Isotype IgG1
Quantity 100μg
Regulatory Status RUO
Species Reactivity Human, Mouse
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Conjugate Unlabeled

This LVUBKM monoclonal antibody recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1). Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. Although it is expressed in both immune and non-immune cells, highest levels of Mcl-1 expression are seen in hematopoietic lineage cells. PI3K activation of AKT results in destabilization and degradation of GSK3 beta, which prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintenance of mature lymphocytes.