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Mcl-1 Mouse anti-Human, Mouse, Clone: LVUBKM, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9047-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15507576

  • £180.20 / 100µg


Estimated Shipment date
from Supplier 31-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This LVUBKM monoclonal antibody recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1). Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. Although it is expressed in both immune and non-immune cells, highest levels of Mcl-1 expression are seen in hematopoietic lineage cells. PI3K activation of AKT results in destabilization and degradation of GSK3 beta, which prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintenance of mature lymphocytes.
Description & Specifications

Specifications

Mcl-1
LVUBKM
Unlabeled
Purified
Murine
100μg
Store at 2-8°C.
Monoclonal
Immunohistochemistry (Formalin/Paraffin)
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
myeloid cell leukemia sequence 1
IgG1
RUO
Primary
Murine