Mcl-1 Mouse anti-Human, Mouse, Clone: LVUBKM, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9047-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15597566

Quantity Price
1 £ 73.93 / 25µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Antigen Mcl-1
Applications Flow Cytometry (Intracellular Staining)
Applications Immunohistochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Isotype IgG1
Concentration 0.5mg/mL
Format Purified
Species Reactivity Human, Mouse
Storage Requirements Store at 2-8°C.
Gene Alias myeloid cell leukemia sequence 1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Host Species Mouse
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Clone LVUBKM
Conjugate Unlabeled
Quantity 25μg

This LVUBKM monoclonal antibody recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1). Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. Although it is expressed in both immune and non-immune cells, highest levels of Mcl-1 expression are seen in hematopoietic lineage cells. PI3K activation of AKT results in destabilization and degradation of GSK3 beta, which prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintenance of mature lymphocytes.