MCL-1 Mouse anti-Human, Mouse, Clone: LVUBKM, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-9047-80
Code : NEW
Additional Details : Weight : 0.09500kg
DescriptionIt is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Mcl-1 (Myeloid cell leukemia-1) is a member of the bcl-2 family. The carboxy terminal of Mcl-1 and bcl-2 share significant sequence homology. Expression of Mcl-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2. Enhanced expression of Mcl-1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation. Like bcl-2, Mcl-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis.
|PBS with 0.09% sodium azide; pH 7.2|
|bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; EAT; MCL1L; MCL1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related)|
|Flow Cytometry, Immunohistochemistry (Paraffin)|
For Research Use Only.