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Invitrogen™ MBP Monoclonal Antibody (2H9)

Product Code. 12827942
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
12827942 100 μL 100µL
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Product Code. 12827942 Supplier Invitrogen™ Supplier No. MA515922

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Description

Mouse Monoclonal Antibody

MA5-15922 targets MBP in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human samples. The MA5-15922 immunogen is purified recombinant fragment of human MBP expressed in E. Coli. . MA5-15922 detects MBP which has a predicted molecular weight of approximately 33kDa.

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MBP
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2H9
Concentration Conc. not determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene MBP
Gene Accession No. P02686, P02688, P04370
Gene Alias 20 kDa microtubule-stabilizing protein; C76307; golli mbp; Golli-mbp; Golli-MBP; myelin basic protein; Golli-Mbp; myelin basic protein; myelin basic protein S; Hmbpr; MBP; MBP S; Mbps; MGC99675; microtubule-stabilizing protein; mld; MOBP; Myelin A1 protein; myelin basic protein; myelin basic protein Golli-mbp; myelin basic protein S; myelin deficient; myelin membrane encephalitogenic protein; Myelin P1 protein; myelin-associated oligodendrocyte basic protein; R75289; shi; shiverer; Unknown (protein for IMAGE:7984318); unnamed protein product
Gene Symbols MBP
Host Species Mouse
Immunogen Purified recombinant fragment of human MBP expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17196, 24547, 4155
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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