Invitrogen™ MBNL1 Recombinant Rabbit Monoclonal Antibody (K01_2N20)

Product Code.	Quantity	unitSize
30824791	100 μL	-
30825001	50 μL	50µL

Product Code. 30824791 Supplier Invitrogen™ Supplier No. MA564118

Description

Rabbit Recombinant Monoclonal Antibody

MBNL1 Recombinant Monoclonal Antibody for Western Blot

EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC pathways that help in growth and proliferation of cells. Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPK pathway. Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. Moreover, EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.

Specifications

• Antigen: MBNL1
• Applications: Western Blot
• Classification: Recombinant Monoclonal
• Clone: K01_2N20
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: 50mM tris glycine with 0.05% BSA, 40% glycerol, 150mM NaCl and 0.01% sodium azide; pH 7.4
• Gene: MBNL1
• Gene Accession No.: Q9NR56
• Gene Alias: DKFZp686P06174; EXP; EXP35; EXP40; EXP42; KIAA0428; MBNL; MBNL1; mKIAA0428; muscleblind like splicing regulator 1; muscleblind-like 1; muscleblind-like 1 (Drosophila); muscleblind-like protein 1; muscleblind-like splicing regulator 1; triplet-expansion RNA-binding protein
• Gene Symbols: MBNL1
• Host Species: Rabbit
• Immunogen: A synthetic peptide of human MBNL1.
• Purification Method: Protein A/G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4154
• Target Species: Human
• Content And Storage: Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG