Invitrogen™ MBD2 Recombinant Rabbit Monoclonal Antibody (24GB460)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30275516	Invitrogen™ MA557472	100 μL
30276250	Invitrogen™ MA557473	20 μL

Description

MBD2 Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.

Specifications

• Antigen: MBD2
• Concentration: 0.8 mg/mL
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9UBB5, Q9Z2E1
• Gene ID (Entrez): 17191, 680172, 8932
• Immunogen: A synthesized peptide derived from human MBD2 (aa 100-165).
• Product Type: Antibody

• Clone: 24GB460
• Content And Storage: -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human, Mouse, Rat
• Gene: Mbd2
• Gene Alias: demethylase; DKFZp586O0821; DMTase; MBD2; MBD2a; methyl-CpG binding domain protein 2; methyl-CpG-binding domain protein 2; Methyl-CpG-binding protein MBD2; NY-CO-41
• Gene Symbols: Mbd2
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography