Invitrogen™ MAVS Monoclonal Antibody (ABM28H9), eBioscience™

Mouse Monoclonal Antibody

Brand:  Invitrogen™ 14-9835-82

Product Code. 17120802

Description

Description: This ABM28H9 monoclonal antibody recognizes human MAVS, a mitochondrial membrane protein also known as VISA, CARDIF or IPS-1. Applications Reported: This ABM28H9 antibody has been reported for use in western blotting, immunocytochemistry and flow cytometry. Applications Tested: This ABM28H9 antibody has been tested by western blotting of human cell line lysates. This may be used at 0.2 μg/mL. This ABM28H9 antibody has also been tested by immunocytochemistry on human cell lines. This may be used at 0.125 μg/mL.

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. MAVS is a mitochondrial membrane protein that was identified as a critical component in the IFN beta signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. MAVS is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. MAVS also interacts with the IKK-alpha, IKK-beta and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. Multiple isoforms of MAVS are known to exist.

Specifications

• Antigen: MAVS
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q7Z434
• Gene Symbols: MAVS
• Immunogen: Recombinant fragment of human MAVS (aa 72-296).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: Western Blot, Immunocytochemistry
• Clone: ABM28H9
• Conjugate: Unconjugated
• Gene: MAVS
• Gene Alias: CARD adapter inducing interferon beta; CARD adaptor inducing IFN-beta; Cardif; D430028G21Rik; IFN-B promoter stimulator 1; IFN-beta promoter stimulator-1; interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IPS1; IPS-1; KIAA1271; MAVS; mitochondrial antiviral signaling protein; mitochondrial anti-viral signaling protein; mitochondrial antiviral-signaling protein; Putative NF-kappa-B-activating protein 031N; virus-induced signaling adapter; virus-induced signaling adaptor; virus-induced-signaling adapter; VISA
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57506
• Content And Storage: 4°C, do not freeze
• Form: Liquid