Invitrogen™ MASTL Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA582955

Product Code. 16349914

Description

Immunogen sequence: TSQLGFHQSN QWAVDSGGIS EEHLGKRSLK RNFELVDSSP CKKIIQNKKT CVEYKHNEMT NCYTNQNTGL TVEVQDLKLS VHKSQQNDCA NKEN Highest antigen sequence indentity to the following orthologs: Mouse - 62%, Rat - 64%.

MASTL or microtubule associated serine/threonine kinase-like belongs to the MAST family, AGC Ser/Thr protein kinase group. MASTL promotes mitotic progression and cell cycle reentry after DNA damage. Loss of MASTL leads to defects in chromosome condensation, separation, and other aspects of mitotic progression, which is primarily mediated by inhibiting PP2A/B55 delta. Overexpression of MASTL is correlated with cancer progression, poor patient survival, and tumor recurrence in various cancers. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus.

Specifications

• Antigen: MASTL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MASTL
• Gene Alias: 2700091H24Rik; C88295; GREATWALL; greatwall kinase homolog; greatwall protein kinase; GW; GWL; hGWL; Mastl; MAST-L; microtubule associated serine/threonine kinase like; microtubule associated serine/threonine kinase-like; microtubule-associated serine/threonine-protein kinase-like; RP11-85G18.2; Serine/threonine-protein kinase greatwall; THC2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84930
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96GX5
• Gene Symbols: MASTL
• Immunogen: Recombinant protein corresponding to Human MASTL. Recombinant protein control fragment (Product #RP-95202).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG