Invitrogen™ MASP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Marca:  Invitrogen™ PA597956

Código de producto. 16550782

Descripción

MASP2 Polyclonal Antibody for IHC (P), ELISA

Mannose (or mannan)-binding lectin (MBL), also known as serum mannosebinding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. Activated MASPs subsequently cleave and activate downstream components of the complement pathway. MASP-3 is an alternatively spliced product from the MASP-1 gene and may function to inhibit MASP-2 by competing for MBL binding and inhibiting the activation of MBLassociated MASP-2.

Especificaciones

• Antigen: MASP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MASP2
• Gene Alias: mannan binding lectin serine peptidase 2; mannan-binding; mannan-binding lectin serine peptidase 1 pseudogene 1; mannan-binding lectin serine peptidase 2; mannan-binding lectin serine peptidase 2 variant 1; mannan-binding lectin serine peptidase 2 variant 2; mannan-binding lectin serine peptidase 2 variant 3; mannan-binding lectin serine peptidase 2 variant 4; mannan-binding lectin serine protease 1 pseudogene 1; mannan-binding lectin serine protease 2; Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain; mannose binding lectin-associated serine protease-2; mannose-binding protein-associated serine protease 2; MAp19; MASP1P1; Masp2; MASP-2; MBL-associated plasma protein of 19 kD; MBL-associated serine protease 2; sb:eu714; small MBL-associated protein; sMAP; wu:fb62a09
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 10747
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: O00187
• Gene Symbols: MASP2
• Immunogen: Recombinant Human Mannan-binding lectin serine protease 2 protein (189-314AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG