Invitrogen™ MARCO Monoclonal Antibody (PLK-1), PE, eBioscience™

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
16330614	Invitrogen™ 12-5447-41	25 Tests
16205340	Invitrogen™ 12-5447-42	100 Tests

Description

Description: This PLK-1 monoclonal antibody recognizes human MARCO, also known as SR-A6 or SCARA2. Applications Reported: This PLK-1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This PLK-1 antibody has been pre-diluted and tested by flow cytometric analysis of human monocyte-derived macrophages. This may be used at 5 μL (0.06 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

MARCO, also known as SR-A6 or SCARA2, is a macrophage surface receptor and a member of the class A scavenger receptor family. As a part of the innate antimicrobial immune system, MARCO can bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. Due to its expression in tumor infiltrating macrophages, and its role in inhibiting immune responses within tumor environment, MARCO has been indicated as a potential target for cancer immunotherapy.

Specifications

• Antigen: MARCO
• Concentration: 5 μL/Test
• Applications: Flow Cytometry
• Conjugate: PE
• Host Species: Mouse
• Regulatory Status: RUO
• Formulation: PBS with BSA and 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q9UEW3
• Gene ID (Entrez): 8685
• Immunogen: Human alveolar macrophages.
• Product Type: Antibody

• Clone: PLK-1
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG3
• Target Species: Human
• Gene: Marco
• Gene Alias: AI323439; Ly112; macrophage receptor MARCO; Macrophage receptor with collagenous structure; MARCO; SCARA2; Scavenger receptor class A member 2; scavenger receptor class A, member 2; SR-A6
• Gene Symbols: Marco
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography