MARCH8 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16872614	Proteintech 14119-1-AP-20UL	20 μL
16862614	Proteintech 14119-1-AP-150UL	150 μL

Description

MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.

Specifications

• Antigen: MARCH8
• Applications: Western Blot, Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: Q5T0T0, Q9DBD2
• Gene ID (Entrez): 220972, 71779
• Immunogen: MARCH8 Fusion Protein Ag5268
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: MARCH8

• Concentration: 0.13 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: c MIR, MARCH VIII, MARCH8, MIR, RING finger protein 178, RNF178
• Gene Symbols: MARCH8
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody